I’ve been listening for several months to the IT conversations podcast. You can also find it on iTunes.
It contains the recordings of very interesting presentations at key conferences, such as those organized by o’reilly media. It also has great interviews, especially those run by Jon Udell “Interviews with innovators”. You can hear directly from the people running those great services such as everyblock.com, govtrack, etc.
I cannot express enough how much I find this inspirational both in terms of content and of initiative. Highly recommended.